TORONTO — Ten starts into the season, Baltimore's Kevin Gausman is still looking for his first win.
Edwin Encarnacion hit a game-ending home run in the 10th inning and the Toronto Blue Jays beat the Orioles 4-3 on Friday night, snapping Baltimore's winning streak at five.
Gausman allowed three runs, two earned, and eight hits in 6 1/3 innings, taking a no-decision for the seventh time in nine outings.
"When you have guys on base every inning, you kind of put yourself in a hole," Gausman said.
Gausman created a jam in the first inning with an errant pickoff throw that allowed Ezequiel Carrera to advance from first to third.
"Just a bad throw, just spiked it right into the ground," Gausman said. "That's kind of the way my whole start went, just back up against the wall and trying to pitch out of jams."
Gausman began the season on the disabled list with a sore right shoulder and made his first start on April 25 at Tampa Bay. He's 0-3 and has not won since Sept. 30, 2015, against Toronto.
Gausman was long gone by the time Encarnacion snapped an 0-for-19 slump with an opposite field shot off Brad Brach (5-1) to begin the 10th.
"They'd been throwing to me outside all day so I just tried to make an adjustment and it worked," Encarnacion said.
Brach lost for the first time since Sept. 28, 2015, also against Toronto. He gave Encarnacion credit for hitting a good pitch.
"Down and away, and maybe up just a tad, but slightly off the plate and he put a good swing on it," Brach said.
It was the fifth walkoff homer of Encarnacion's career.
"He's a feared guy," Blue Jays manager John Gibbons said.
Drew Storen (1-2) pitched one inning for the win.
Chris Davis hit a two-run homer and Jonathan Schoop added a solo blast for the Orioles, who came in tied with Seattle for the major league lead with 89 home runs.
"We didn't do a whole lot other than a couple of home runs," Orioles manager Buck Showalter said.
Blue Jays right-hander Marco Estrada held the Orioles without a hit for the first four innings after taking a no-hitter into the eighth inning against Boston in his previous start.
Estrada lost his no-hit bid at Fenway on a home run and suffered the same fate in this one when Schoop drilled a one-out homer in the fifth, connecting on an 0-2 pitch.
Estrada allowed three runs and four hits in six innings.
Baltimore led 3-2 after Davis homered in the top of the sixth but Toronto tied it in the bottom half when Russell Martin hit an RBI single off the glove of diving shortstop Manny Machado.
"When you get the lead, you're supposed to shut the door, especially that next inning," Gausman said. "That was what I was most upset about."
Davis has 15 home runs in 42 career games in Toronto. He's hit 33 homers against the Blue Jays since 2008, more than any other opponent.
Ten of Baltimore's 36 errors have been made by pitchers.
When Davis mishandled Carrera's grounder in the ninth, the ball caromed straight to Brach, who tossed it back to Davis in time for the rare 3-1-3 putout.
Blue Jays: OF Jose Bautista (right thigh) was held out of the starting lineup. Bautista left Thursday's game after six innings with tightness in his thigh. Manager John Gibbons said he hopes Bautista will return Saturday. ... SS Troy Tulowitzki (strained right quadriceps) suffered a setback while running the bases in an extended spring training game Friday.
Orioles: RHP Mike Wright (3-3, 5.14) allowed one run in seven innings to beat Kansas City in his previous start, winning his second straight decision. Wright took the loss in an April 19 home start against Toronto, allowing three runs in six innings.
Blue Jays: LHP J.A. Happ (6-3, 3.57) allowed six runs in five innings in an 11-0 loss at Detroit on Monday. It was just the second time in 12 starts he failed to complete six innings. Happ has not faced Baltimore this season.