De Niro and Streep memorably starred together in 1978's "The Deer Hunter," as well as 1984's "Falling in Love" and 1996's "Marvin's Room."
FilmNation Entertainment announced Tuesday that it acquired the rights for "The Good House" from Jane Rosenthal, De Niro's producing partner. She will produce the film for Tribeca Productions along with FilmNation's Aaron Ryder and Karen Lunder.
Writing the script will be Michael Cunningham, the Pulitzer Prize-winning author of "The Hours."
It will be the fourth film together for the 69-year-old De Niro and the 64-year-old Streep.