CINCINNATI - The Philadelphia Phillies couldn't overcome their costly mistakes on the bases on Saturday.
The Reds threw out Marlon Byrd at the plate to end the sixth inning and Carlos Ruiz to end the seventh of a 6-5 loss to Cincinnati.
The play against Byrd had the Phillies particularly upset, causing manager Ryne Sandberg's first ejection as a manager and just the second of his career.
My argument was the catcher (Devin Mesoraco) blocked the plate before he had the ball," Sandberg said. "Byrd almost twisted his ankle with indecision. It has gone against us three times with different scenarios. Everyone wants to know what the rule is."
Crew chief Tom Hallion asked for a review. The review lasted 2:21 and prevented the Phillies from bringing the tying run to the plate in the inning.
Ruiz led off the sixth with his second homer of the season, and Rollins hit a two-run shot in the seventh, his eighth homer of the season and second in two days.
"I can't give you an educated response because I don't know what the rule is," Byrd said. "I was waiting for a lane. I was going to slide outside and get my hand in."
Jay Bruce homered and drove in three runs and the Reds snapped a three-game losing streak.
Todd Frazier also homered and the Reds overcame homers by Byrd, Ruiz and Jimmy Rollins and sending the Phillies to their seventh loss in eight games.
Alfredo Simon (8-3) allowed seven hits and three runs with three strikeouts in six innings. Jonathon Broxton pitched a scoreless eighth inning and Aroldis Chapman pitched the ninth for his eighth save.
The Reds wasted no time snapping their 17-inning scoreless streak, scoring in the first inning. Billy Hamilton drew a leadoff walk, stole second on the first pitch to Skip Schumaker and hustled to third on Schumaker's groundout to Rollins at shortstop, setting up Bruce's sacrifice fly.
The Phillies answered with Byrd's two-run homer in the second, his ninth of the season.
Frazier led off the bottom of the second with his team-leading 13th homer of the season, giving him home runs in three of his past four games.
Frazier sparked Cincinnati's fourth-inning go-ahead rally with a single to right field and stolen base. Zack Cozart drove him in with a sinking line drive to right-center field that Ben Revere got a glove on with a diving try before the ball trickled away. Cozart went to third on Ramon Santiago's single and scored on Hamilton's sacrifice fly.
The Phillies threatened in the fifth, getting runners to second and third with one out, prompting Sandberg to pinch-hit John Mayberry Jr. for starting pitcher Roberto Hernandez.
Hernandez (2-4), is 0-3 in seven starts since his most recent win on May 4, allowed four hits and four runs with three walks and two strikeouts in four innings. He also hit a batter.
"I threw a lot of pitches," Hernandez said. "It is a little frustrating not to pitch deeper in the game. I tried to keep the ball down, but there were too many 2-0, 3-1 counts.
The Reds also ran on Hernandez, stealing three bases while they were out-hit 11-6.
"He had 80 pitches and was having trouble with the running game," Sandberg said.
Bruce followed Brandon Phillips' fifth-inning leadoff walk with his fourth homer of the season and first since April 20 against the Cubs in Chicago. The homer was his first in Cincinnati since April 3 and the 100th of his career at Great American Ball Park.
Notes: Reds 1B Joey Votto will begin an injury rehab assignment with Triple-A Louisville on Sunday. Votto hasn't played since going on the disabled list on May 21, retroactive to May 16, with a quadriceps strain in his left knee, the same knee on which he had two surgeries in 2012. ... Bruce's walk in the third inning was his first in 16 games since he was walked three times by Milwaukee on May 1. ... Sandberg was given his first career ejection after arguing a review decision in the top of the sixth inning. ... Rollins needs six hits to pass Hall of Famer Mike Schmidt and become Philadelphia's career hits leader.