Charter school founder Dorothy June Brown is charged with leading a conspiracy that misused $6.7 million in public school funds.
Federal prosecutors say Brown paid herself multiple salaries from her four schools, plus management fees, taking in $4 million in a two-year period alone.
Two of her school executives are also on trial, while two others pleaded guilty before trial.
Jurors appear to be struggling with some of the approximately 60 counts.
They have asked if they can return verdicts on only some charges. But U.S. District Judge R. Barclay Surrick has told them to keep working.
Deliberations are set to resume Wednesday.