Many of them, he says, "are already Americans," whether they're here legally or not. He says immigrants simply want a decent life for themselves and their children, just as his great grandparents did.
Biden's comments came in a speech to Pennsylvania political leaders gathered in New York on Saturday.
It was the second time in a week that Biden addressed immigration publicly. In a recent online chat, he called out House Speaker John Boehner for blocking a vote on a Senate package that includes a pathway to citizenship.
Biden says that majorities of Americans in both parties support such a pathway.