The MAC champion Falcons will face Pittsburgh of the ACC in the Little Caesars Pizza Bowl on Dec. 26.
The Falcons (10-3) beat previously undefeated Northern Illinois 47-27 in the MAC title game at Ford Field on Friday night, their fifth straight win.
It's the third bowl bid in five seasons for Bowling Green and the 11th in school history. But it's also the program's first trip to the Pizza Bowl in 10 years.
"We are excited to play in a great environment like Ford Field again, so close to our campus, with our fans and students being able to make the trip," Falcons coach Dave Clawson said.
Pitt will be making its sixth straight trip to a bowl game and will be the first ACC team to make the trip to Detroit.
The Panthers, who went 3-5 in their first season in their new league, are 2-1 against Bowling Green since 1999.
"Bowling Green was impressive not only in their MAC Championship win, but all season long and we have a competitive game of football ahead," Pitt coach Paul Chryst said.
The Falcons rank fifth in the nation in scoring defense at just 14.8 points a game, although they gave up 42 points in a loss at Indiana.
Pitt has been one of the worst teams in the country at running the ball, but Tom Savage has thrown for 2,834 yards and 21 touchdowns this season.