GAME OF THE WEEK: No. 24 Duke at North Carolina. The league's most celebrated basketball rivalry finally has significance well beyond the Triangle in football. A Duke win would clinch the Blue Devils' first 10-win season, seal up the outright Coastal Division title and send them to the ACC title game to face No. 2 Florida State. None of the tiebreaker scenarios have the Tar Heels in the title game, but a win would keep alive the possibility of a five-way tie for the division. Duke has won seven straight games while North Carolina has reeled off five straight victories.
BEST MATCHUP: No. 6 Clemson at No. 10 South Carolina. Tajh Boyd can settle once and for all whether he has any fear of Jadeveon Clowney. The South Carolina defensive end touched off a minor controversy over the summer when he said he "can tell Tajh Boyd is scared back there" and the Clemson QB fired back that "I'm not afraid of anybody." There are four ACC-vs.-SEC this week and this is by far the highest profile one.
INSIDE THE NUMBERS: Maybe Syracuse will be the team that can slow down Boston College's Andre Williams. The nation's leading rusher has at least 172 yards in each of his last five games and only two teams—Southern Cal and Clemson—have held him under 100 yards. Syracuse has the ACC's fourth-best run defense, giving up 133.5 yards per game, but Williams already has shredded the two of the ACC's top three run defenses in Virginia Tech (166 yards, two touchdowns) and Florida State (149 yards).
LONG SHOT: Pittsburgh looks capable of becoming the latest to knock off a Miami team that plunged from No. 7 in the nation to out of the polls. If Pitt DT Aaron Donald can keep the pressure on QB Stephen Morris and RB Dallas Crawford—and QB Tom Savage can make enough plays in near-freezing conditions at Heinz Field—the 2 1/2-point underdog Panthers can give the Hurricanes a fourth loss in five games.
PLAYER TO WATCH: Maryland's C.J. Brown has six career 100-yard rushing performances—no ACC quarterback has more—and now has the pleasure of facing a North Carolina State defense that has struggled during the team's slide. In losing seven straight, the Wolfpack have been gashed by both passing QBs (East Carolina's Shane Carden) and running QBs (North Carolina's Marquise Williams). N.C. State has given up at least 427 yards in five of its past six games.
Compiled by AP Sports Writer Joedy McCreary in Raleigh, N.C.