LOUISVILLE, Ky.—Shoni Schimmel led five players in double figures with 22 points and Megan Deines scored 17 off the bench to help No. 11 Louisville rout Big East Conference-foe Pittsburgh 78-45 Saturday for its sixth straight win.

Deines made 7 of 11 shots in just 22 minutes of action, Bria Smith tallied 11 points and Antonita Slaughter and Sara Hammond chipped in 10 apiece for the Cardinals (20-4, 8-2), who shot 48 percent (17 of 35) in the first half.

Pittsburgh (9-14, 0-10), led by Brianna Kiesel's 14 points, made just 7 of 24 shots in the opening frame and trailed 39-20 at the break. The Panthers committed 26 turnovers, which led to 27 points for Louisville.

The Cardinals opened the second half with a 14-3 run to stretch their lead to 30, 53-23.

The Panthers held a 34-32 rebounding edge but got just 11 points off the bench.