Police in Northampton County say the two were in a station wagon that collided with a pickup truck at about 9:45 a.m. Wednesday in Lower Nazareth Township.
The county coroner's office says 67-year-old Clifford Babin Jr. of Bethlehem was pronounced dead at the scene.
The Lehigh County coroner's office says 88-year-old Gertrude Babin was taken to St. Luke's Hospital in Bethlehem, where she was pronounced dead a half-hour later.
Police told The (Allentown) Morning Call that the driver of the other car had minor to moderate injuries.
The cause of the accident remains under investigation.