Police said 17-year-old Christopher Malcolm was shot in the chest in the Overbrook Park residence, and 13-year-old Rohan Bennett was then shot in the head as he was trying to run away.
Police called just after 7:30 p.m. Tuesday said Bennett died at the scene and Malcolm died shortly afterward at a hospital.
The shooter fled with a large bag, and police say they are searching for a suspect.
Homicide Capt. James Clark told reporters Wednesday that more than $100,000 in cash and a large amount of prescription drugs were found in the home.