Classes at RMU Downtown will begin Aug. 25. The school will offer two bachelor's degree programs, four master's degree programs and various certificate programs at the downtown center.
The school is now based in Moon Township, about 10 miles west of the city, and has about 4,800 students.
The school sold what was left of its former downtown campus to Duquesne University two years ago, but promised to return to the city at some point.
The school eventually plans to offer programs at sites in Southpointe, near Canonsburg, about 15 miles south of the city, and in Monroeville, a suburb about 15 miles east of the city.