The Luzerne County coroner's office said 55-year-old Bernard Edwards was pronounced dead after the Pittston blaze.
The fire was reported at about 1 a.m. Wednesday in the Pittston building.
Building owner Tony Zambetti said Edwards lived in a first-floor apartment.
He said Edwards had both legs amputated and used a wheelchair, but it wasn't clear whether the disability hampered his attempts to escape the blaze.
The cause of the fire remains under investigation.