The crash has been cleared and traffic is starting to flow smoothly, according to a state Department of Transportation advisory that was issued about 7:05 p.m.
Two people were taken to an area hospital for treatment, according to York County 911 radio transmissions.
Reported earlier: A crash in the southbound lanes of Interstate 83 in the area of the North George Street exit in Manchester Township has blocked the lanes.
The crash was reported about 6:10 p.m.
Two people are believed to have suffered non-life threatening injuries, according to York County 911 radio transmissions.
The crash is between the North George Street exit and the Route 30 exit.
Traffic has began to back up as emergency crews work the scene.
Traffic is now being diverted off the highway.