York Revolution starting pitcher Mike McClendon went six innings for the first time this season and held Lancaster to a pair of runs.
The Revs' offense collected eight hits and came back by scoring a pair of runs in the seventh inning to get a one-run lead.
Still, it wasn't enough.
Barnstormers' bottom-of-the-lineup batter James Skelton, who tallied four home runs all of last season, hit his fourth of this season in the seventh inning with a two-run shot over the short porch at Lancaster's Clipper Magazine Stadium. It proved to be the difference in Lancaster's 4-3 win in the middle game of a three-game set against the visiting Revs on Wednesday.
The War of the Roses rivals will head to the rubber game of the series Thursday when Revs' left-hander Chris Cody (0-1, 7.82 ERA) takes on righty Brian Grening (1-1, 3.00).
With Wednesday's loss, the Revs dropped back to .500 at 9-9 overall while also falling to 5-4 in one-run games this season.
Wednesday also marked the fifth time this year York went on to lose after holding a lead.
McClendon, a former big leaguer, had his best outing of the season thus far, holding Lancaster (12-6) to the pair of runs on six hits with three strikeouts and one walk in six innings, throwing 54 of his 83 pitches for strikes. It's just the fourth time so far this year a Revs starting pitcher has gone six innings.
In the top of the seventh inning the Revs went up, 3-2, on a Travis Garcia (2-for-4, RBI, run scored) RBI double and a Sean Smith sacrifice fly RBI. It put McClendon in line for his third win of the year.
But reliever Julio DePaula (0-1) gave up the two-run homer in the bottom of the seventh inning, marking the fourth time in six outings this year DePaula has surrendered at least a run. The left-hander has now given up seven runs (six earned) in 6.1 innings of work, which equates to an 8.52 ERA.
The Revs had a chance to tie it or possibly take the lead in the ninth inning when they loaded the bases with two outs and brought to the plate Eric Patterson, who hit a pair of homers in Tuesday's 6-5 win over Lancaster.
But Patterson, a former big leaguer, struck out swinging, going 0-for-4 at the dish in the loss.
York right fielder Johan Limonta (1-for-4) extended his hitting streak to nine consecutive games, the longest streak by a Revs' batter this season.