Clear Channel announced Monday that Kendrick Lamar, Shakira, Ed Sheeran and Arcade Fire will also take the stage at the May 1 awards show in Los Angeles. Lady Gaga, Katy Perry, Lorde and Coldplay's Chris Martin will make appearances.
Contenders for artist of the year include Rihanna, Maroon 5, Justin Timberlake, Imagine Dragons and Macklemore & Ryan Lewis.
The awards will air live on NBC from the Shrine Auditorium starting at 8 p.m. Eastern.
Luke Bryan, Pitbull, Ariana Grande and Thirty Seconds to Mars will also perform during the three-hour telecast.