Friends and colleagues in the U.S. Caribbean territory say Martinez died Sunday of complications from pneumonia. He had been hospitalized since mid-January.
Martinez was known for energetic stand-up routines and a slew of memorable characters, including an elderly pot-smoking woman dubbed Dona Mary Jane. He performed before 17,000 fans last year at a stadium in Puerto Rico's capital of San Juan. He was also a TV show host.
Gov. Alejandro Garcia Padilla is praising Martinez as an "extraordinary actor and comedian" and has ordered flags to be flown at half-staff at all public buildings for three days.
Funeral arrangements are pending. Martinez is survived by his parents and his sister.