Producers said Thursday the "Harry Potter" actor will star in Martin McDonagh's "The Cripple of Inishmaan," directed by Tony Award-winner Michael Grandage.
Previews begin April 12 at the Cort Theatre with an opening scheduled for April 20.
The show tells the story of a young man who tries to become a movie star when a Hollywood film is being made nearby.
Radcliffe made his West End debut in 2007 and Broadway debut in 2008 in "Equus." He returned to Broadway in 2011 for "How to Succeed in Business Without Really Trying."
"The Cripple of Inishmaan" was mounted in London last year with Radcliffe and previously had off-Broadway productions at the Public Theater and at the Atlantic Theater Company.