Veteran "X-Men" director and producer Bryan Singer hinted at the next installment via Twitter on Thursday when he wrote, "(hash)Xmen (hash)Apocalypse 2016!"
Fox confirmed the film will open in wide release Memorial Day weekend, on May 27, 2016.
Apocalypse is a major villain from the "X-Men" comics who appeared in the 1980s.
Singer has worked on all the Marvel mutant-focused films since the first "X-Men" was released in 2000.
He's also directing the next movie in the franchise, "X-Men: Days of Future Past."
Scheduled for a May 23, 2014, release, the film will star Hugh Jackman, Patrick Stewart, Halle Berry, Jennifer Lawrence, Anna Paquin, James McAvoy, Michael Fassbender, Shawn Ashmore and Nicholas Hoult.