The Disney Animation film takes viewers inside the world of vintage arcade games, where characters such as Q-Bert, Clyde the Ghost from "Pac-Man" and Kano from "Mortal Kombat" consider their video-game gigs day jobs, and after 30 years, Wreck-It Ralph is sick of his.
John C. Reilly, Sarah Silverman, Jack McBrayer and Jane Lynch are among the voice stars. Reilly and Silverman appeared alongside director Rich Moore at Thursday's panel.
Moore announced that Grammy-winner Skrillex will contribute music to the soundtrack and "Firefly" star Alan Tudyk will play a role in the film.
Comic-Con continues through Sunday.