Mexico's Mana took home five awards, while Colombian pop star Shakira earned four.
La Adictiva Banda San Jose de Mesillas group won best new artist.
Thursday's live show was hosted was presented by State Farm. Telemundo broadcast the production from the BankUnited Center at the University of Miami in Coral Gables.
Juanes, Pitbull and Marc Anthony—along with the top winners—performed. Anthony received a Billboard Hall of Fame Award for his global, artistic influence.
Billboard winners are selected based on sales and radio airplay.