The blaze broke out at about 9:30 p.m. Tuesday.
Fire Commissioner Lloyd Ayers says the man was found in a second-floor bedroom of the home, which had partially collapsed.
The Philadelphia Daily News (http://bit.ly/YuU8PM) reports the victim's name was not immediately released. Two women were taken to a hospital with unknown injuries.
The cause of the fire, which also damaged a nearby house, is still under investigation.
Information from: Philadelphia Daily News, http://www.philly.com