The southbound lanes have since been reopened.
Crews cleared the scene just after 10 p.m., according to radio transmissions.
A crash in Springfield Township has closed the southbound lanes of Interstate 83.
First responders were dispatched to the area of Exit 8, the Glen Rock exit, just after 9 p.m. for the reported rollover crash, according to York County 911.
Radio transmission indicated numerous people were injured but most suffered minor injuries.
Check back later for additional details.