The Eagles pounded the Colonials' defense for 428 rushing yards in a recording a 45-17 victory.
The triumph gave Dover at least a share of the York-Adams Division II title. The Eagles, 4-0 in league play and 7-2 overall, can clinch the championship outright next week by defeating Susquehannock. New Oxford fell to 3-1 in league action and 6-3 overall.
Dover, averaging 296 rushing yards a game entering the showdown, ran the ball 54 times against New Oxford while attempting just three passes.
The Eagles, leading 24-10 at halftime, blew the game open by scoring the first 21 points of the second half.
"In the locker room, the coaches were telling us (at halftime), don't be satisfied, go out and put the nail in the coffin," Dover offensive lineman and linebacker Cameron Beckman said.
"The backs can't run without the line. All of our running backs give tremendous efforts."
Three Eagles' running backs eclipsed 100 rushing yards on Friday night.
Isaiah Green ran for 115 yards, Dorran Ledbetter for 107 and Jake McLean for 103. Ledbetter scored three touchdowns while Green, McLean and Gabe Jackson supplied one TD apiece.
"It's amazing," Ledbetter said when asked what it was like to be part of a trio of 100-yard rushers.
"That line up front, they did a lot of work."
Supplying the blocks were Beckman, Matt Farr, Tyler Jacobson, Isaiah Schultz, Neil Querry, Levi Murphy and Dan Bisking.
Beckman also recovered a fumble to set up is team's first touchdown.
"It starts up front, and the kids up front do a great job," Dover head coach Eric Lam said. "Fortunately, we were able to keep it pretty simple, and physically, we were able to do what we needed to do."
Lam, in his first year as the team's head coach, passed the credit for the success this season to the players.
"I'm proud of the players. We talked about this since February and March, trying to do the best we can. They (the players) believe in what we asked of them, and they've done a great job."
Dover never trailed against New Oxford after scoring the first two touchdowns of the game on runs by Green and Ledbetter.
New Oxford's Wes Beans carried the ball seven times for 104 yards and a touchdown. Beans broke a 78-yard TD run in the second quarter.
The Eagles will now focus on next Friday when they'll bid to complete a perfect Division II record.
"Two years ago, we had to share the title (with West York and Northeastern), and that irritated me," Beckman said.